Kildare headquartered BAM Ireland is creating 500 new construction jobs.
It has secured the Bolands Quay Development contract at is the site of the old Boland's Mill in Dublin's docklands.
Three new landmark buildings with office, retail, residential and cultural space will be developed as part of the project.
Some of the protected mill buildings will also be restored, along with the creation of a new civic plaza looking onto the waterfront at Grand Canal Dock.
The firm's base is in Kill