Roger Federer will begin the defence of his Australian Open title against world number 99, Denis Istomin.
The Swiss is in the same half of the draw as Rafa Nadal, who opens up against Aussie qualifier, James Duckworth.
Andy Murray's first hurdle is the Spaniard, Roberto Bautista Agut.
Women's top seed Simona Halep could face both Williams sisters en route to a potential quarter final.
They're all in the same section, with Halep facing Kaia Kanepi in round 1, while Serena Williams begins the defence of her title against Germany's Tatjana Maria.