Keith Earls' autumn series seems to be over, without even playing a game.
The winger has returned to Munster to rehab the hamstring injury that forced him to miss Saturday's win over the Springboks.
Prop John Ryan has also returned to the province to treat a calf problem.
Back rows Tommy O'Donnell and Dan Leavy will again miss this week's game with Fiji.
While Jordi Murphy and Sean Reidy have been added to the squad.