Kildare's Tadhg Beirne has been handed a first Six Nations start for Saturday's meeting with Wales in Cardiff - he replaces the injured Iain Henderson.
There's another change to the pack with Sean O'Brien returning at openside for Josh van der Flier.
And having been named in last week's starting line-up but ultimately withdrawing from the side that beat France - Rob Kearney has again been named at full-back.
Kieran Marmion's likely to make a first appearance of the championship, having been named among the replacements.
Wales are unchanged for the game at the Principality Stadium, as they chase the Grand Slam.