Andrew Conway and Jordan Larmour will make their World Cup debuts in Sunday's Pool A against Scotland.
They've been drafted into the back three with Rob Kearney and Keith Earls both ruled out.
Larmour will start at full-back with Conway on the right-wing.
C-J Stander has been given the nod to start at number-eight ahead of Jack Conan in a back row of Josh Van Der Flier and Peter O’Mahony.
Ireland: Jordan Larmour; Andrew Conway, Garry Ringrose, Bundee Aki, Jacob Stockdale; Jonathan Sexton, Conor Murray; Cian Healy, Rory Best (capt), Tadhg Furlong; James Ryan, Iain Henderson; Peter O’Mahony, Josh van der Flier, CJ Stander.
Replacements: Niall Scannell, Dave Kilcoyne Andrew Porter, Tadhg Beirne, Jack Conan, Luke McGrath, Jack Carty, Chris Farrell
In the opening game, Russia v Japan. At half time, Japan lead 12-7 .
In the Premier League tonight.
Southampton host Bournemouth - with the winner able to move up to third in the table.
Both sides have two wins, two defeats and a draw from their first five matches.
SSE Airtricity League, leaders Dundalk make the trip to Waterford this evening with a 10-point advantage.
Second-place Shamrock Rovers host St Pat's in a Dublin derby.
Derry City play Bohemians.
Cork City host Finn Harps. UCD play Sligo.
Today’s racing is in Ballinrobe from 3.30 and in Dundalk from 4.50pm
Reminder to join Eoin Beatty for the Weekend previews from 6.25 this evening: looking ahead to all the weekend Kildare sport. The main GAA action is in the county senior, intermediate and junior hurling championships games tomorrow and Sunday. Kfm will have live updates on all the games on tomorrow’s and Sunday’s Sportsbeat from 2pm each day.