The clash of Derry City and Sligo Rovers at the Ryan McBride Brandywell Stadium marks the return of the SSE Airtricity League after a 21 week hiatus.
Sligo will be hoping to win their first points of the Premier Division season having lost all four matches so far.
That kicks off at 5:45 while champions Dundalk can join leaders Shamrock Rovers on 15 points with a win tonight.
They kick off against St Patrick's Athletic AT Oriel Park at 7:45.
In the First Division Athlone Town play Wexford, Bray Wanderers play Cobh Ramblers, Galway United take on Cabinteely and UCD host Longford Town.
All games kick off at 7.45pm.