James Lowe omitted as he recovers from injury
The pair are the only uncapped players in the squad.
Ulster Second row Kieran Treadwell, who won the last of his three Irish caps in 2017, is included.
He replaces Ultan Dillane, who is omitted, because he moves abroad at the end of the season.
Jack Carty, Johnny Sexton and Joey Carbery are the out-halves.
The squad will be captained by Johnny Sexton, who earned his 100th cap last time against Japan.
IRELAND Squad
Backs (17)
Bundee Aki (Connacht/Galwegians) 33 caps
Robert Baloucoune (Ulster/Enniskillen) 2 caps
Joey Carbery (Munster/Clontarf) 27 caps
Jack Carty (Buccaneers/Connacht) 10 caps
Craig Casey (Munster/Shannon) 4 caps
Andrew Conway (Munster/Garryowen) 27 caps
Keith Earls (Munster/Young Munster) 96 caps
Jamison Gibson Park (Leinster) 12 caps
Mack Hansen (Connacht) uncapped
Robbie Henshaw (Leinster/Buccaneers) 53 caps
James Hume (Ulster/Banbridge) 1 cap
Hugo Keenan (Leinster/UCD) 16 caps
Jordan Larmour (Leinster/St Mary's College) 30 caps
Michael Lowry (Ulster/Banbridge) uncapped
Conor Murray (Munster/Garryowen) 92 caps
Garry Ringrose (Leinster/UCD) 37 caps
Johnny Sexton (Leinster/St Mary’s College) 101 caps CAPTAIN
Forwards (20)
Ryan Baird (Leinster/Dublin University) 6 caps
Finlay Bealham (Connacht/Buccaneers) 18 caps
Tadhg Beirne (Munster/Lansdowne) 25 caps
Jack Conan (Leinster/Old Belvedere) 22 caps
Gavin Coombes (Munster/Young Munster) 2 caps
Caelan Doris (Leinster/St Mary’s College) 12 caps
Tadhg Furlong (Leinster/Clontarf) 52 caps
Cian Healy (Leinster/Clontarf) 112 caps
Iain Henderson (Ulster/Academy) 65 caps
Rob Herring (Ulster/Ballynahinch) 23 caps
Ronan Kelleher (Leinster/Lansdowne) 16 caps
Dave Kilcoyne (Munster/UL Bohemians) 45 caps
Peter O’Mahony (Munster/Cork Constitution) 79 caps
Tom O’Toole (Ulster/Ballynahinch) 2 caps
Andrew Porter (Leinster/UCD) 40 caps
James Ryan (Leinster/UCD) 40 caps
Dan Sheehan (Leinster/Lansdowne) 2 caps
Nick Timoney (Ulster/Banbridge) 2 caps
Kieran Treadwell (Ulster/Ballymena) 3 caps
Josh van der Flier (Leinster/UCD) 35 caps
Development Player
Cian Prendergast (Connacht)